Kristin M. Burkholder, Ph.D.
Location
Credentials
Education
Expertise
- Microbiology
Post-Doctoral Training
University of Michigan Medical School, 2010-2012 (Ann Arbor, Michigan)
Research
Current research
My lab studies how bacterial pathogens interact with their host cells and with other microbes. I am particularly interested in (i) strategies used by pathogens to avoid destruction by host innate intracellular defenses, and (ii) mechanisms by which nonpathogenic probiotic bacteria can mitigate pathogen infection.
Selected publications
REFEREED PUBLICATIONS (*undergraduate student author, **M.S. student author)
Roese, K.H.C.**, C. Torlone*, L.A. Cooper*, L. Esposito*, A.M. Deveau, U.S.R. R枚se, and K. M. Burkholder. 2023. Pyrogallol impairs staphylococcal biofilm formation via induction of bacterial oxidative stress. Journal of Applied Microbiology. 134: 12.
Vorse, J.G.**, C.T. Moody*, L.C. Massoia*, J.J. Perry, K.M. Burkholder and C.J. Byron. 2023. Effect of post-harvest processing methods on the microbial safety of edible seaweed. Journal of Applied Phycology. .
Olson, Z.H., C. Torlone*, C. Russel*, C. Wood*, J. Welch* and K.M. Burkholder. 2022. Foraging risk in scavenging ecology: A study of scavenger behavior and patterns of bacterial growth. Basic and Applied Ecology. .
Cusson, A.J.**, K.M. Burkholder, C.J. Byron, G.S. Grebe and A.M. Deveau. 2021. Impact of time of harvest and drying method on antimicrobial activity of Sacharina latissima against two Staphylococcus aureus strains. Applied Phycology. DOI: 10.1080/26388081.2021.1996208
Barberi, O.M.**, C.J. Byron, K.M. Burkholder, A.T. St. Gelais and A.K. Williams. 2019. Assessment of bacterial pathogens on edible macroalgae in coastal waters. Journal of Applied Phycology. https://doi.org/10.1007/s10811-019-01993-5.
Burkholder, K.M., D. H. Fletcher*, L. Gileau* and A. Kandolo*. 2019. Lactic acid bacteria decrease Salmonella enterica Javiana virulence and modulate host inflammation during infection of an intestinal epithelial cell line. FEMS Pathogens and Disease. 77(3). doi:10.1093/femspd/ftz025.
Deveau, A.M., Z. Miller-Hope**, E. Lloyd*, B.S. Williams*, C. Bolduc*, J.M. Meader*, F. Weiss* and K.M. Burkholder. 2016. Antimicrobial activity of extracts from macroalgae Ulva lactuca against clinically important Staphylococci is impacted by lunar phase of macroalgae harvest. Letters in Applied Microbiology. 62(5):363-371.
Tranchemontagne, Z.R.**, R.B. Camire*, V.J. O'Donnell, J. Baugh* and K.M. Burkholder. 2016. Staphylococcus aureus strain USA300 perturbs acquisition of lysosomal enzymes and requires phagosomal acidification for survival inside macrophages. Infection and Immunity. 84(1):241-253.
Abuaita, B.H., K.M. Burkholder, B.R. Boles and M.X.D. O'Riordan. 2015. The endoplasmic reticulum stress sensor inositol-reducing enzyme 1伪 augments bacterial killing through sustained oxidant production. MBio. 6(4):e00705.
Burkholder, K.M., J. Perry, C. Wobus, H. Showalter, V. Kapuria, N. Donato and M.X.D. O'Riordan. 2011. A small molecule deubiquitinase inhibitor increases localization of iNOS to the macrophage phagosome and enhances bacterial killing. Infection and Immunity. 12:4850-7.
Mishra, K.K., Mendonca, M., Aroonnual, A., Burkholder, K.M. and Bhunia, A.K. 2011. Genetic organization and molecular characterization of the secA2 locus in Listeria species. Gene. 489:76-85.
Burkholder, K.M and Bhunia, A.K. 2010. Listeria monocytogenes uses Listeria Adhesion Protein (LAP) to promote bacterial transepithelial translocation, and induces expression of LAP receptor Hsp60. Infection and Immunity. 78: 5062-5073.
Jagadeesan B., Koo O.-K., Kim K.-P., Burkholder K.M., Mishra K., Aroonnual A., Bhunia A.K. 2010. LAP, an alcohol acetaldehyde dehydrogenase enzyme in Listeria, promotes bacterial adhesion to enterocyte-like C